bạn edit template cái này ListBoxItem rồi chình trigger tùy ý bạn thôi. Sau khi chỉnh xong bạn xét thuộc tính ItemContainerStyle là cái template đó.

https://stackoverflow.com/questions/15632493/wpf-listbox-turn-off-hover-effect

<Style TargetType="{x:Type ListBoxItem}">
        <Setter Property="Background" Value="Transparent"/>
        <Setter Property="HorizontalContentAlignment" Value="{Binding HorizontalContentAlignment, RelativeSource={RelativeSource AncestorType={x:Type ItemsControl}}}"/>
        <Setter Property="VerticalContentAlignment" Value="{Binding VerticalContentAlignment, RelativeSource={RelativeSource AncestorType={x:Type ItemsControl}}}"/>
        <Setter Property="Padding" Value="2,0,0,0"/>
        <Setter Property="Template">
            <Setter.Value>
                <ControlTemplate TargetType="{x:Type ListBoxItem}">
                    <Border x:Name="Bd" BorderBrush="{TemplateBinding BorderBrush}" BorderThickness="{TemplateBinding BorderThickness}" Background="{TemplateBinding Background}" Padding="{TemplateBinding Padding}" SnapsToDevicePixels="true">
                        <ContentPresenter HorizontalAlignment="{TemplateBinding HorizontalContentAlignment}" SnapsToDevicePixels="{TemplateBinding SnapsToDevicePixels}" VerticalAlignment="{TemplateBinding VerticalContentAlignment}"/>
                    </Border>
                    <ControlTemplate.Triggers>
                        <Trigger Property="IsSelected" Value="true">
                            <Setter Property="Background" TargetName="Bd" Value="{DynamicResource {x:Static SystemColors.HighlightBrushKey}}"/>
                            <Setter Property="Foreground" Value="{DynamicResource {x:Static SystemColors.HighlightTextBrushKey}}"/>
                        </Trigger>
                        <MultiTrigger>
                            <MultiTrigger.Conditions>
                                <Condition Property="IsSelected" Value="true"/>
                                <Condition Property="Selector.IsSelectionActive" Value="false"/>
                            </MultiTrigger.Conditions>
                            <Setter Property="Background" TargetName="Bd" Value="{DynamicResource {x:Static SystemColors.InactiveSelectionHighlightBrushKey}}"/>
                            <Setter Property="Foreground" Value="{DynamicResource {x:Static SystemColors.InactiveSelectionHighlightTextBrushKey}}"/>
                        </MultiTrigger>
                        <Trigger Property="IsEnabled" Value="false">
                            <Setter Property="Foreground" Value="{DynamicResource {x:Static SystemColors.GrayTextBrushKey}}"/>
                        </Trigger>
                    </ControlTemplate.Triggers>
                </ControlTemplate>
            </Setter.Value>
        </Setter>
    </Style>

Cái này hơi phức tạp, bạn tham khảo thôi, chủ yếu như này là đủ rồi :

<Style TargetType="{x:Type ListBoxItem}">
        <Setter Property="Background" Value="Transparent"/>
        <Setter Property="HorizontalContentAlignment" Value="{Binding HorizontalContentAlignment, RelativeSource={RelativeSource AncestorType={x:Type ItemsControl}}}"/>
        <Setter Property="VerticalContentAlignment" Value="{Binding VerticalContentAlignment, RelativeSource={RelativeSource AncestorType={x:Type ItemsControl}}}"/>
        <Setter Property="Padding" Value="2,0,0,0"/>
        <Setter Property="Template">
            <Setter.Value>
                <ControlTemplate TargetType="{x:Type ListBoxItem}">
                    <Border x:Name="Bd" BorderBrush="{TemplateBinding BorderBrush}" BorderThickness="{TemplateBinding BorderThickness}" Background="{TemplateBinding Background}" Padding="{TemplateBinding Padding}" SnapsToDevicePixels="true">
                        <ContentPresenter HorizontalAlignment="{TemplateBinding HorizontalContentAlignment}" SnapsToDevicePixels="{TemplateBinding SnapsToDevicePixels}" VerticalAlignment="{TemplateBinding VerticalContentAlignment}"/>
                    </Border>
                    <ControlTemplate.Triggers>
                        <Trigger Property="IsMouseOver" Value="True">
                            <Setter Property="Background" Value="Transparent"/>
                        </Trigger>
<Trigger Property="IsSelected" Value="True">
                            <Setter Property="Background" Value="Transparent"/>
                        </Trigger>
                    </ControlTemplate.Triggers>
                </ControlTemplate>
            </Setter.Value>
        </Setter>
    </Style>

ItemContainerStyle của ListBoxItem

Set background của thằng đó lại